A Comparison of Propofol-based Total Intravenous Anesthesia and Desflurane Anesthesia on NK cell Activity After Major Hepatic Resection in Hepatocellular Carcinoma Patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20190423003

Enrollment

Registered

2019-04-23

Start date

2019-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma Anesthetic agents suppress NK cell activity Anesthetic agents decline IL&#45

Interventions

HCC patient undergoing hepatectomy under general anesthesia&#44

propofol total intravenous technique.,HCC patient undergoing hepatectomy under general anesthesia&#44

desflurane inhaled technique.

Basic Science,Basic Science

Propofol&#45

TIVA ,Desflurane

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: HCC patients undergoing hepatectomy ASA physical status 1-3 acceptable for epidural catheter insertion

Exclusion criteria

Exclusion criteria: Recurrent HCC patients Severe systemic disease Chronic opioid or sedative drug or alcohol uses Refuse for participation Immunocompromised patients Immunosuppressive drug received patients history of suspected malignant hyperthermia

Design outcomes

Primary

Measure	Time frame
Percentage of NK cell activity at postoperative 24 hour flow cytometry	—

Secondary

Measure	Time frame
Interleukin-6 at postoperative 24 hour ELISA,Interleukin 10 at postoperative 24 hour ELISA	—

Countries

Thailand

Contacts

Public ContactKirada Apisutimaitri

Chulalongkorn University

kirada.api@gmail.com0814834274

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

A Comparison of Propofol&#45;based Total Intravenous Anesthesia and Desflurane Anesthesia on NK cell Activity After Major Hepatic Resection in Hepatocellular Carcinoma Patients