Patients age 18-
Conditions
Interventions
Omeprazole plus sucralfate suspension use,Omeprazole use
Omeprazole 20 mg oral bid ac before food 1 hour
Active Comparator Drug,Placebo Comparator Drug
Study group has two combine drugs for 2 weeks
-
Omeprazole 20 mg oral bid ac before food 1 hour
-
Sucralfate suspension (1gm/ 5 ml) 5 ml oral qid ac before food 1 hour,Control group has single drug for 2 weeks
-
Sponsors
Srinagarind Hospital Khonkaen University
Srinagarind Hospital Khonkaen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients age 18-75 years old in the Srinagarind Hospital between years 2019-2020 and receive a diagnosis of cirrhosis child-pugh A and B from any cause with presented esophageal varices by esophagogastroduodenoscopy. • Patients accept for endoscopic variceal ligation for primary prophylaxis upper gastrointestinal bleeding. • Voluntary to participate in the research
Exclusion criteria
Exclusion criteria: Patients with contraindications to endoscopic varices ligation under general anesthesia such as do not cooperate, patients with risk bleeding cannot be solved by providing blood components (INR> 1.5, platelet <80,000). • Patients had history of endoscopic variceal ligation or sclerotherapy or surgery. • Patients presents with ulcer or Barrett’s metaplasia at varices before endoscopic variceal ligation. • Patients do not stop antiplatelet at least 10 days. • Pregnancy or lactation. • Organ transplant. • Drug allergy (omeprazole or sucralfate or general anesthesia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion ulcer patients 2 week EGD and evaluation ulcer (positive or negative) | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse drug reaction 2 weel Present of nausia or vomitting, Dysphagia, GI bleed (Positive of negative) | — |
Countries
Thailand
Contacts
Public ContactKawin Tangvoraphonkchai
Outcome results
None listed