Asymptomatic hyperuricemia Hyperuricemia Uric acid Urate Curcumin Tumeric Urine uric acid clearance
Conditions
Interventions
Curcumin capsule 500mg intake twice daily,Placebo capsule (same appearance/smell/taste as curcumin capsule) 500mg intake twice daily
Active Comparator Drug,Placebo Comparator Drug
Sponsors
Department of medicine, Phramongkutklao Hospital
Thai Rheumatism association
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 18 years of age or older Asymptomatic hyperuricemia, defined as serum urate level more or equal to 7 mg/dL in male and 6 mg/dL in female, without history of arthritis, tophus, or diagnosed of gout
Exclusion criteria
Exclusion criteria: eGFR less than 30 ml/min/1.73m2 AST and/or ALT more or equal to 3 times above upper normal limits 15% or more change in serum urate prior to entering the study Pregnant or breast-feeding women History of cur cumin allergy, real or ureteric stone, biliary tract obstruction and hematologic malignancy, planned for chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum urate 2 Blood test | — |
Secondary
| Measure | Time frame |
|---|---|
| safety profile 1 subject informed,Urine uric acid clearance 2 24-hour urine test,fasting plasma glucose 2 blood test,lipid profiles 2 blood test | — |
Countries
Thailand
Contacts
Public ContactPannipa Bupparenoo
Phramongkutklao Hospital
Outcome results
None listed