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Telomere length and its relationship with age, oxidative stress, inflammation, metabolism, physical performance, cognition and quality of life in Thai subjects with normal body weight and overweight/obesity

Telomere length and its relationship with age, oxidative stress, inflammation, metabolism, physical performance, cognition and quality of life in Thai subjects with normal body weight and overweight/obesity

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20190417005
Enrollment
136
Registered
2019-04-17
Start date
2019-05-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Normal weight and overweight/obese individuals

Interventions

Physical performance measurement will use 1) 85%VO2peak by cycling ergometer for a cardiorespiratory test. The protocol is following the steps
warm up for 3 minutes&#44
start the first workload with the proper watts based on their background and health status for 3 minutes&#44
increased the workload every three minutes up to 5 workloads or until exhaustion and reach the stop criteria. The criteria to stop the test are composed with RER higher than 1.15&#44
a participant cannot maintain a constant pedal rate at least 60 rpm&#44
heart rate increase almost reach 85% of maximal heart rate&#44
rating of dyspnea and fatigue at least 9/10 and 18/20 respectively. 2) Hand grip dynamometer will use for the strength test. the dynamometer must be properly fit the size of participant’s hands. Th
extends the arm at their side with anywhere from 90&#45
180 degree elbow angle. The arm does not contact any part of the body. Three attempts are made with each hand. The highest value of both right and left hand record.
Experimental Other
Physical performance

Sponsors

Khon Kaen University
Lead Sponsor
The Royal Golden Jubilee (RGJ) Ph.D. Programme The Thailand Research Fund (TRF),Graduate school (Biomedical Science program), Khon Kaen University
Collaborator

Eligibility

Sex/Gender
All
Age
20 Years to 59 Years

Inclusion criteria

Inclusion criteria: Normal weight individuals 1) Age 20 – 59 years 2) 18.5 < BMI < 23 kg.m&#45;2 3) No consumption of supplementation at least 3 months 4) No regular smoking and alcohol drinking Overweight and obese individuals 1) Age 20 – 59 years 2) 23 ≤ BMI ≥ 34.9 kg.m&#45;2 3) Not enrollment in any reducing weight program 4) No consumption of supplementation at least 3 months 5) No regular smoking and alcohol drinking

Exclusion criteria

Exclusion criteria: 1) Pregnancy 2) Abnormal EKG 3) Diagnosis with hypertension 4) Diagnosis with dyslipidemia 5) Diagnosis with type 2 diabetes mellitus 6) Diagnosis with kidney and liver diseases 7) Chronic infectious diseases 8) Autonomic neuropathy 9) Bone fracture

Design outcomes

Primary

MeasureTime frame
Telomere length 1 day Real time PCR,metabolism 1 day indirect calorimetry—

Secondary

MeasureTime frame
oxidative stress 1 day colorimetry based method,inflammation 1 day Particle enhanced immunoturbidimetry,Cardiorespiratory test 1 day 85% VO2peak by ergometer,cognition 1 day Montreal cognitive assessment,quality of life 1 day Short form 36,Strength test 1 day Hand grip dynanometer—

Countries

Thailand

Contacts

Public ContactRujira Nonsa&#45;ard

Graduate school (Biomedical Sciences program)&#44; Khon Kaen University

Rujira.n@kkumail.com+6692-282-4285

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026