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Comparing Non-invasive Diagnostic Methods for Arteriovenous Fistula Stenosis: A Prospective Study

Comparing Non-invasive Diagnostic Methods for Arteriovenous Fistula Stenosis: A Prospective Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20190325002
Enrollment
Unknown
Registered
2019-03-25
Start date
2017-12-25
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arteriovenous fistula stenosis hemodialysis&#44

Interventions

The ultrasound dilution technique utilized the Transonic HD Monitor. The measurement was taken twice within 30 – 60 minutes after HD initiation. Ultrafiltration was turned off during measurement. Th
arterial (a) and venous (v) samples were drawn at a blood flow rate (Qb) of 350 – 400 mL/min&#44
and the systemic (s) sample was drawn from the arterial tubing after the blood pump was stopped. Blood urea nitrogen concentrations were measured in all samples. The recirculation (R) and access flow
BUNa))/(BUNs&#45
BUNv)) Qa =BPF × ((1&#45
R))/R ,Nephrologist and Radiologist performed color Doppler ultrasonography at a different time. A7&#45
15 MHz linear transducer was used. Peak systolic velocity and AVF diameter were measured at the anastomosis&#44
juxta&#45
anastomosis&#44
body&#44
and outflow site of the AVF. Access flow (Qa) was calculated as follow: Access flow (mL/min) = Time&#45
averaged mean velocity × π × radius2 × 60 The mean access flow value of the two results was used. The operator dependence of the Qa measurement was evaluated by comparing the intra&#45
assay coefficient of variation
ultrasound dilution,urea dilution,Doppler ultrasonography

Sponsors

Siriraj hospital Mahidol university
Lead Sponsor
Routine to research unit&#44
Collaborator
Siriraj
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.patients who had features of AVF stenosis (i.e., include limb edema, loss of AVF collapse after arm elevation) 2.high venous pressures of over 200 mmHg on three consecutive HD runs. 3. patients with the other dialysis parameters were also reviewed for additional evidence (i.e., unexplained hemodialysis inadequacy, difficulty needling).

Exclusion criteria

Exclusion criteria: 1. patient who does not want to participate in the trial. 2. patient who could not proceed on all investigations.

Design outcomes

Primary

MeasureTime frame
sensitivity of three methods to detect AVF stenosis compare with gold standard ( fistulography) ultrasound dilution, urea dilution, and Doppler ultrasonography

Secondary

MeasureTime frame
sensitivity of venous pressure and physical examination for detect AVF stenosis compare with gold standard (fistulography) sensitivity and specificity

Contacts

Public ContactSukit Raksasuk

nephrology division, faculty of medicine, Siriraj hospital

sukit.ruk@mahidol.ac.th+66863435942

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026