Melioidosis Genetic Melioidosis genetics infection
Conditions
Interventions
Participants with melioidosis,Participants who do not have melioidosis but have other bacterial infections. ,Health participant
Other,Other,Other
Melioidosis cases,Other infection controls,Healthy controls
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Melioidosis patients Diabetes Cohort inclusion criteria (MD cohort) - Age greater than or equal to 18 years - Suspected cases of Melioidosis on Day 0 with HbA1c confirmed diabetes status. - Willingness to participate in the study and written, informed consent obtained from the patient or their relative. - Resident in North East Thailand for at least the previous 2 years Melioidosis patient Non-diabetes Cohort inclusion criteria (MN cohort) - Age greater than or equal to 18 years - Suspected cases of Melioidosis on Day 0 with HbA1c confirmed non-diabetes status. - Willingness to participate in the study and written, informed consent obtained from the patient or their relative - Resident in North East Thailand for at least the previous 2 years Healthy control with Diabetes Cohort inclusion criteria (HD cohort) - Age greater than or equal to 18 years - Currently well or out-patient with HbA1c confirmed diabetes status - Willingness to participate in the study and written, informed consent obtained from the participant - Resident in North East Thailand for at least the previous 2 years Healthy control Non-diabetes Cohort inclusion criteria (HN cohort) - Age greater than or equal to 18 years - Currently well with no other medical problems requiring hospital specialist supervision with HbA1c confirmed non-diabetes status - Willingness to participate in the study and written, informed consent obtained from the participant - Resident in North East Thailand for at least the previous 2 years Infection control with Diabetes Cohort inclusion criteria (ID cohort) - Age greater than or equal to 18 years - Culture-confirmed bacteraemia of a Gram negative pathogenic bacteria other than Burkholderia pseudomallei with HbA1c confirmed diabetes status - Willingness to participate in the study and written, informed consent obtained from the patient or their relative - Resident in North East Thailand for at least the previous 2 years Infection control with Non-diabetes Cohort inclusion criteria (IN cohort) - Age greater than or equal to 18 years - Culture-confirmed bacteraemia of a Gram negative pathogenic bacteria other than Burkholderia pseudomallei with HbA1c confirmed non-diabetes status - Willingness to participate in the study and written, informed consent obtained from the patient or their relative - Resident in North East Thailand for at least the previous 2 years
Exclusion criteria
Exclusion criteria: Melioidosis Cohort (including diabetic and non-diabetic) exclusion criteria: - Current TB or treatment of TB within the last 6 months Documented HIV infection, chemotherapy, or other immunosuppressant therapy in the last 12 months. - Pregnancy Healthy Cohort (including diabetic and non-diabetic) exclusion criteria: - Previous history of melioidosis - Significant acute intercurrent illness - Current TB or treatment of TB within the last 6 months - Documented HIV infection, chemotherapy, or other immunosuppressant therapy in the last 12 months - Pregnancy Gram Negative bacteraemia (including diabetic and non-diabetic) exclusion criteria: - Previous history of melioidosis - Current TB or treatment of TB within the last 6 months - Documented HIV infection, chemotherapy, or other immunosuppressant therapy in the last 12 months - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bacteria that associated with melioidosis severity and variable disease outcomes single time point at patient admission Summary statistics of bacterial genetic factors,Patient biomarkers that associated with melioidosis severity and variable disease outcomes single time point at patient admission Summary statistics of host biomarkers | — |
Secondary
| Measure | Time frame |
|---|---|
| host diabetic status modulate the effect of the bacterial in disease single time point at patient admission Summary statistics of bacterial genetic factors being modulated by host diabetic status,host diabetic status modulate the effect of the patient biomarkers in disease single time point at patient admission Summary statistics of host biomarkers being modulated by host diabetic status | — |
Countries
Thailand
Contacts
Public ContactDr.Kamolchanok Chewapreecha
Mahidol-Oxford Tropical Medicine Research Unit (MORU)
Outcome results
None listed