Lung Mechanics, Asynchronies, and Flow Limitation in Assisted Invasive Mechanical VENTilation

Lung Mechanics, Asynchronies, and Flow Limitation in Assisted Invasive Mechanical VENTilation (MAFAI VENT project)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20190318003

Enrollment

367

Registered

2019-03-18

Start date

2019-03-26

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory failure Mechanical ventilation Respiration, Artificial Lung Compliance Airway Resistance Lung Diseases, Obstructive Positive-Pressure Respiration, Intrinsic Respiratory Distress Syndrome, Adult

Interventions

Changing the settings of the ventilators and collect the data measured by the machine&#39

s sensors via the RS&#45

232 port. &#45

Record baseline waveforms for asynchronies &#45

Override patients&#39

spontaneous effort (if detected) by hyperventilation protocol &#45

Detection of EFL by PEEP reduction method (5&#45

10 cmH2O) &#45

Measurements of lung mechanics by end&#45

expiratory and end&#45

inspiratory pause

Experimental Other

Measurements of lung mechanics&#44

asynchronies and flow limitation

Eligibility

Sex/Gender

All

Age

15 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Admitted to the intensive and intermediate critical care wards 2. Receiving invasive mechanical ventilation via a ventilator that is capable of transmitting data through RS-232 port 3. The relatives consent for the patient to participate in the research 4. Permission to do the study is granted from the clinicians in charge 5. Able to initiate the data collection within 48 hours after ventilator use

Exclusion criteria

Exclusion criteria: 1. Severe hypoxemia (SpO2 < 90%) which is uncorrectable 2. Unstable hemodynamics which cannot be corrected (mABP < 60 mmHg, SBP > 180 mmHg, heart rate < 40/min or > 160/min) 3. The patient has already participated in the current study within 48 hours from the previous data collection 4. The patient or the relatives deny to participate in the study 5. Contraindicated to ventilation at ZEEP (ARDS)

Design outcomes

Primary

Measure	Time frame
The descriptive data regarding lung mechanics, asynchronies and flow limitation 1 hour Data collected via ventilators output port	—

Secondary

Measure	Time frame
The predictors of specific lung conditions, asynchronies, or flow limitation 7 days Chart review	—

Countries

Thailand

Contacts

Public ContactDetajin Junhasavasdikul

Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand

detajin@yahoo.com66 2 2011629

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026