Effectiveness of silver diamine fluoride on primary teeth

Effectiveness of silver diamine fluoride and fluoride varnish for preventing and arresting initial proximal caries in primary teeth

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20190315003

Enrollment

180

Registered

2019-03-15

Start date

2019-02-12

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

&#45

Interventions

1.Dentist will brush and use dental floss for each participant. 2.Soft tissue will be protected with petroleum jelly to avoid staining and mucosal irritation. 3.Moisture will be controlled by using co

brush for 1 minute. (Total use of SDF is 1 drop or 25 microliter for primary dentition and mixed dentition) 5.Samples will not be allowed to eat or drink for 30 minutes ,1.Dentist will brush and use d

brush (Total use of fluoride varnish are 0.25 ml for primary dentition and 0.5 ml for mixed dentition) 5.Samples are asked to refrain from eating for at least two hours and brushing at nighttime of t

Experimental Drug,Active Comparator Drug,Placebo Comparator No treatment

Applying silver diamine fluoride and giving oral health care instruction ,Applying fluoride varnish and giving oral health care instruction ,Giving oral health care instruction

Eligibility

Sex/Gender

All

Age

4 Years to 6 Years

Inclusion criteria

Inclusion criteria: -Healthy children -No history of allergic to fluoride and silver -Presence full posterior contact at least one quadrant. -Presence at least one initial proximal caries lesion which is detected by bitewing radiograph examination and is categorized to scored 1 - 3 according to ICCMSTM radiographic score (radiolucency in outer half of enamel to outer half of dentin).

Exclusion criteria

Exclusion criteria: -Uncooperative children who cannot take bitewing radiograph and tolerance to dental procedure. -Children are received professional fluoride use within 6 months. -Posterior teeth with enamel or dentine defects such as enamel hypoplasia, and amelogenesis imperfecta.

Design outcomes

Primary

Measure	Time frame
initial caries progression detected from bitewing radiographs 2 years follow up time caries transition score	—

Secondary

Measure	Time frame
developing caries 2 years follow up caries detected from bitewing radiographs at follow up time	—

Contacts

Public ContactVarangkanar Jirarattanasopha

Faculty of Dentistry, Mahidol University, Bangkok, Thailand

jvarang@gmail.com66817522571

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026