Lumbar spinal stenosis -
Conditions
Interventions
Pregabalin 75 mg po,
bid
Naproxen 250 mg po,
bid
Omeprazole 20 mg po,
od
Paracetamol 500 mg po,
tid ,Naproxen 250 mg po,
tid
Active Comparator Drug,Placebo Comparator Drug
Pregabalin group,Placebo group
Sponsors
Faculty of Medicine, Khon Kaen university
Faculty of Medicine,
Khon Kaen university
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: - Diagnosis of lumbar spinal stenosis with symptoms of intermittent neurogenic claudication, VAS for leg pain 4-10, numbness and/or weakness of at least 1 month and confirmation of lumbar spinal stenosis with imaging - Age 40-80 years
Exclusion criteria
Exclusion criteria: - Tandem spinal stenosis - Herniated nucleus pulposus - Spinal tumor - Spinal infection - Compression fracture of thoracolumbar or lumbar spine - Previous lumbar spine surgery - Sciatic entrapment neuropathy - Piriformis syndrome - Pre-existing hip or knee joint disorder - Diagnosis of depression - Poor control diabetes - Liver or kidney disease (ALT and AST abnormal 2 fold and Serum Cr > 1.4 or GFR < 30 ml/min. - Allergy of pregabalin - Pregnancy or lactation period - Contraindication to NSAID ; recent UGIB, MI, HF, severe uncontrolled HT and NSAID induced asthma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Leg pain intensity score 8 weeks Self-report questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| ODI, RM, NRS back pain, painDetect questionnaire 4 and 8 weeks self-report questionnaire | — |
Countries
Thailand
Contacts
Public ContactKriangkrai Wittayapairoj
Khon Kaen university
Outcome results
None listed