Although the association between coffee and SUA have been shown in many studies, there is no prospective cohort study between instant caffeine and decaffeine coffee. Therefore, this study was designe caffeine coffee, decaffeine coffee, uric acid
Conditions
Interventions
We design by using commercial instant caffeine coffee in the first period and then cross over by using commercial instant decaffeine coffee in the second period in the same healthy men participants gr
the first week is the control period,
in which participants underwent diet control,
but receive no other intervention. The following 3 weeks are the interventional period,
in which participants consume 2 g/d of commercial instant caffeine coffee,
according to their assigned experimental groups. The last week is the follow-
up period after commercial instant caffeine coffee has been discontinued and this period is also a wash out period before crossing over to commercial instant decaffeine coffee. After a wash out period
all same participants were repeated protocol but 2 g/d of commercial instant decaffeine coffee were applied instead of commercial instant caffeine coffee. ,We design by using commercial instant caffei
in which participants consume 4 g/d of commercial instant caffeine coffee,
up period after commercial instant
2 gram of Caffeine and follow by Decaffeine coffee ,4 gram of Caffeine and follow by Decaffeine coffee ,6 gram of Caffeine and follow by Decaffeine coffee
Sponsors
The Royal College Physicians of Thailand
์ีืNaresuan university
Eligibility
Sex/Gender
Male
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Healthy men were recruited from the internal medicine and health care staff of Naresuan University Hospital. The inclusion criteria were men, age 20-60 years old; having normal renal and hepatic function tests.
Exclusion criteria
Exclusion criteria: The exclusion criteria were history of gout, hypertension, heart rate more than100 beat/min, history of ischemic heart disease and arrhythmia; use of medication including ACEI or ARB, ethambutol, pyrazinamide, aspirin, cyclosporine, nicotinic acid, loop diuretic, etc. or nutritional supplement including vitamin C that affect the SUA level; estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73m2; abnormal serum aspartate aminotransferase (AST) and/or alanine transaminase (ALT); and 15% or more change in SUA during the control period(day0 to day7). However, if participants who be included and take coffee tablet have any serious side effects including severe disturbed normal sleep pattern, severe headache, blood pressure more than140/90mmHg and heart rate more than 100 beat/min or arrhythmia , the participants will be withdrawal from this protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a change in the SUA level after coffee consumption At day 0, 7, 28, 35, 56, 63 of intervention peroid serum uric acid level by enzymatic method | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes included changes in uric acid clearance, serum xanthine oxidase inhibitory activi At day 7, 28, 35, 56, 63 of intervention peroid 24 hr. urine uric acid, xantine oxidase activity kit and review of history in all participants a | — |
Countries
Thailand
Contacts
Public ContactPatapong Towiwat
Naresuan University
Outcome results
None listed