A comparison of analgesic efficacy between Amitriptyline and Mianserin in chronic low back pain patients: A randomized double-blind controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20190303001

Enrollment

Registered

2019-03-03

Start date

2019-03-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic low back pain low back pain tricyclic antidepressant mianserin amitriptyline

Interventions

incremental amitriptyline dosage form 10 mg/day to 50 mg/day,incremental mianserin dosage form 10 mg/day to 50 mg/day

Active Comparator Drug,Active Comparator Drug

Amitriptyline,Mianserin

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. 18 - 65 years old 2. Chronic low back pain for more than 3 months with Numerical rating scale; NRS > 4 3. Able to read and write 4. Without any cancer

Exclusion criteria

Exclusion criteria: 1. Allergy to Amitriptyline and/or Mianserin 2. Psychiatric problem 3. Pregnancy 4. Benign prostatic hyperplasia, glaucoma, high intra-ocular pressure, arrhythmia 5. Planning for pain intervention

Design outcomes

Primary

Measure	Time frame
Pain score 1, 2, 3, 5, 6 ,9 ,12 week Numeric rating scale	—

Secondary

Measure	Time frame
Function Disabilities 1, 2, 3, 5, 6 ,9 ,12 week Oswestry version 1.0,Mental status 1, 2, 3, 5, 6 ,9 ,12 week DASS 21,Quality of life 1, 2, 3, 5, 6 ,9 ,12 week EQ-5D-5L	—

Countries

Thailand

Contacts

Public ContactSuratsawadee Wangnamthip

Department of Anesthesiology, Siriraj Hospital

suratsawadee.wang@gmail.com0819261509

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026