acute gout attack within 72 hours after onset Allopurinol,
Conditions
Interventions
early allopurinol
starting allopurinol ar first day of study,Late allopurinol
starting allopurinol ar 14th day of study
Experimental Drug,No Intervention Drug
Early allopurinol,Late allopurinol
Sponsors
Navamindradhiraj University Research Fund
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Patients > 18 years old presented with an acute gout attack within 72 hours after onset, and crystal-proven gout by arthrocentesis founded MSU crystals and at least one of the following - Frequent attack ≥ 2/year, tophi by clinical exam or imaging study, CKD stage 2 or worse (Estimated Glomerular Filtration Rate 8 mg/dL during attack or comorbidities (at least one of following; hypertension, ischemic heart disease or congestive heart failure)
Exclusion criteria
Exclusion criteria: 1. CKD stage 5 (eGFR < 15) or on Renal replacement therapy 2. Prior use of uric lowering agents past month 3. History of adverse reactin to allopurinol or colchicine 3. Ongoing cancer treatment 4. concomitant use of azathioprine or cyclosporin 5. taking xanthine oxidase inhibitor or uricosuric agent withih 1 month 6. AST, ALTand/or ALP level more than 2 times of upper normal limit 7. Neurologic deficit resulting in decreased pain sensatin around the involve joints 8. During intubation 9. Inability to return for examinations 10. presence of HLA-B*5801 genes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time to complete resolution of acute gouty attack between early and late initiation of allopurinol 5 visit (day1, day5-9, day 14, day 19-23 and day28) visual analog scale and physical examination | — |
Secondary
| Measure | Time frame |
|---|---|
| time to clinical resolution of the acute gout attack between early and late allopurinol group 5 visit (day1, day5-9, day 14, day 19-23 and day28) visual analog scale ,relapse of arthritis 5 visit (day1, day5-9, day 14, day 19-23 and day28) questionaire,Laboratory parameter (Serum uric acid,eGFR, ESR, CRP) 3 visit (day1, day 14, and day28) blood test | — |
Countries
Thailand
Contacts
Public ContactPanchalee Satpanich
Faculty of medicine Vajira Hospital
Outcome results
None listed