Parkinson'
Conditions
Interventions
Standard Triple therapy (Omeprazole 20 mg bid,
amoxicillin 1 g bid,
clarithromycin 500mg bid) x 14 days
Experimental Drug
H.Pyroli eradication
Sponsors
Thammasat University
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adults (>18 years old) with idiopathic Parkinson's disease Levodopa therapy required; any formulation is acceptable. Hoehn & Yahr stage 2-4 in the off state Motor complications; wearing off Normal cognition (TMSE >24) On stable doses of anti-parkinsonian medications or stable DBS adjustment.
Exclusion criteria
Exclusion criteria: Atypical parkinsonism or secondary parkinsonism Severe dysphagia History of gastric cancer, peptic ulcer, duodenal ulcer, or gastric surgery History of previous brain surgery for PD Prior treatment for H.pylori Recent use of proton-pump inhibitor, antibiotics Allergy to penicillin, amoxicillin, clarithromycin, rabeprazole, metronidazole Inability to tolerate or participate in testing in the morning in an off state Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Off time 1 month Average total daily off time from patient symptom diaries in hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of UPDRS motor scores 1 month The Unified Parkinson's Disease Rating Scale (UPDRS) | — |
Countries
Thailand
Contacts
Public ContactPraween Lolekha
Faculty of Medicine, Thammasat University
Outcome results
None listed