Thai armies who are at risk of malaria Plasmodium vivax malaria,
Conditions
Interventions
-
Experimental Drug,Experimental Drug,Experimental Drug
CYP2D6 Normal metabolizer,CYP2D6 intermediate metabolizer,CYP2D6 poor metabolizer
Sponsors
Chulalongkorn university
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: For CYP2D6 gene analysis 1. Thai army male who has been performed in Thai-Cambodia border areas 2. Aged 18 to 60 years 3. Who had a history with malaria infection from the Thai-Cambodia border area (between January 1, 2012 and December 31, 2017) For primaquine pharmacokinetics analysis 1. Participants in CYP2D6 gene analysis and known CYP2D6 status as PM, IM, NM 2. Aged 18 to 60 years 3. Who has a normal BMI (18 to 25 kg/m2) 4. Who has a normal physical examination
Exclusion criteria
Exclusion criteria: For primaquine pharmacokinetics analysis 1. Who continue receiving food supplement, herb, and medication regularly esp. CYP2D6 inhibitor(s), ABC transporter inhibitor esp. P-gp inhibitor(s) 2. Who received antimalarial treatment during the preceding 4 weeks 3. Who currently has malaria infection and signs of severe malaria 4. Who had an underlying disease that contraindication and/or precaution in primaquine using 5. Who had a history of gastrointestinal diseases, hepatic disease, kidney disease 6. Who knew a history of G6PD deficiency 7. Who is smoking 8. Who is drinking alcohol regularly; hazardous (8-15 scores), harmful (16 to 19 scores) and alcohol dependence (more than 20 scores) according to AUDIT 9. Who had a history of substance or drug addiction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PK parameters of primaqine (PQ) and 5,6-o-PQ in CYP2D6 genetic different Thai army population after drug administration LC-MS/MS | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of CYP2D6 genetic polymorphisms in Thai army population after participants signed informed consent Real-time PCR and Extra-long PCR | — |
Countries
Thailand
Contacts
Public ContactWaritda Pookmanee
Royal Thai Army, Medical Depot Division.
Outcome results
None listed