FindTrial
Sign In

Comparing the efficacy of Nidepine and Cardepine in lowering blood pressure after cardio-aortic surgery: a randomized, double-blinded controlled trial

Comparing the efficacy of Nidepine and Cardepine in lowering blood pressure after cardio-aortic surgery: a randomized, double-blinded controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20190206003
Enrollment
Unknown
Registered
2019-02-06
Start date
2016-08-24
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

We carried out prospective randomized double blind controlled trial in a cardio vascular thoracic intensive care unit (ICU). Patients who underwent cardiac or aortic arch surgery were enrolled and con Hypertension Cardiac surgery Calcium channel blocker Nicardepine

Interventions

We carried out prospective randomized double blind controlled trial in a cardio vascular thoracic intensive care unit (ICU). Patients who underwent cardiac or aortic arch surgery were enrolled and con
switching to an oral antihypertensive agent&#44
or discharge from the ICU.,We carried out prospective randomized double blind controlled trial in a cardio vascular thoracic intensive care unit (ICU). Patients who underwent cardiac or aortic arch su
or discharge from the ICU.
Active Comparator Drug,Active Comparator Drug
Nidepine,Cardipine

Sponsors

Universal Medical Industry, Thailand
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Patients aged more than 18 years’ old who underwent a cardiac or an aortic arch surgery were enrolled and continuously observed for blood pressure during their admission in the intensive care unit. Those with post-operative hypertension, defined as systolic blood pressure > 140 mmHg.

Exclusion criteria

Exclusion criteria: Patients were excluded from the study if there were any of these criteria: supine heart rate > 150 beats/min or supraventricular tachycardia during the immediate post-operative period, sternal drain output > 200 ml in the first hour, hypercarbia (pCO2 > 40 mmHg), clinically significant hepatic disease, recent cerebrovascular accident within the past 3 months, allergic or intolerant to CCB or pregnancy.

Design outcomes

Primary

MeasureTime frame
Blood pressure lowering 15 min and 30 min after start treatment Blood pressure level after start treatment—

Secondary

MeasureTime frame
Post operative complication Until discharge from ICU Event and hospital stay—

Countries

Thailand

Contacts

Public ContactPatomphon Ekkarat

Cardio vascular thoracic suregery Chulalongkorn Hospital

e.patomphon@gmail.com0896454982

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026