The differential diagnosis between the TB pleuritis and the malignant pleural effusion (MPE) is difficult because the clinical manifestations are the same. the accurate diagnostic test are important. gene expression tuberculous pleuritis malignant pleural effusion
Conditions
Interventions
malignant pleural effusion group,
meet all inclusion criteria
(1) age not less than 18 years old
(2) lymphocyte predominated exudative pleural effusion
(3) no contraindication to pleural tapping and biopsy
(4) sign informed consent b
any of the two following
(1) PCR-
TB from the pleural fluid or pleural tissue or sputum report the mycobacterioum tuberculosis organism
(2) Mycobacterial culture from the pleural fluid or pleural tissue or sputum report the mycobacte
any of the following
(1) the pathology from the pleural biopsy report the granulomatous pleuritis and the patient'
s clinical symptoms improve from the tuberculosis treatment
(2) The acid fast bacilli staining from the pleural fluid or pleural tissue or sputum report positive and the patient'
s clinical symptoms improve from the tuberculosis treatment
3) Probable diagnosis is the finding of the lymphocyte predominated exudative pleural effusion and the patient'
s clinical symptoms improve from the tuberculosis treatment
Diagnostic,Diagnostic
control group,study group or case group
Sponsors
Ratchadapiseksompotch Research Fund
Department of Medical Sciences,
Ministry of Public Health,
Thailand
Eligibility
Sex/Gender
All
Age
1 Years to 2 Years
Inclusion criteria
Inclusion criteria: 1. Age not less than 18 year-old 2. The mononuclear cell predominated exudative pleural effusion 3. The subjects display voluntary for thoracocentesis, pleural biopsy and finally receiving the diagnostic result of TB pleuritis (case group) or malignant pleural effusion (control group) 4. The subjects sign consent form before the data collection
Exclusion criteria
Exclusion criteria: 1. The subjects have any contraindication to the invasive procedure, such as bleeding disorder. 2. The polymorphonuclear cell predominated exudative pleural effusion 3. The unknown of the final diagnostic result of pleural effusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The level of each gene expression (copies/micro-lite) immediate after enrollment or within 2 weeks if the patient, who diagnosed as the TB pleuritis, rece Droplet digital PCR (copies/micro-lite) | — |
Secondary
| Measure | Time frame |
|---|---|
| contraceptive implant removal duration From the start to the end of the procedure Record time in second ,Success rate Immediate after the entire contraceptive rod is removed Success or failure,Satisfaction Immediate after contraceptive implant removal procedure 5 point Likert scale ,Side effect of anesthesia after applying the anesthesia(Ethyl chloride spray or lidocaine Record side effect of anesthesia | — |
Contacts
Public ContactKamon Kawkitinarong
Faculty of Medicine, Chulalongkorn University, Thailand
Outcome results
None listed