Radioiodine refractory differentiated thyroid cancer TERT promoter mutations prevalence radioiodine refractory differentiated thyroid cancer TERT promoter mutations
Conditions
Interventions
Radioiodine refractory differentiated thyroid cancer was given definition by american thyroid association,
met at least 1 of the following
​1. The malignant/metastatic tissue does not ever concentrate RAI (no uptake outside the thyroid bed at the first therapeutic WBS) or
2. The tumor tissue loses the ability to concentrate RAI after
avid disease (in the absence of stable iodine contamination) or
3. RAI is concentrated in some lesions but not in others or
4. Metastatic disease progresses despite significant concentration of RAI or
Basic Science
Radioiodine refractory differentiated thyroid cancer
Sponsors
Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University
Chulalongkorn university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Age at diagnosis >/= 18 year-old and - Radioiodine refractory differentiated thyroid cancer that had tumor specimen at KCMH.
Exclusion criteria
Exclusion criteria: Radioiodine refractory differentiated thyroid cancer specimens that unable to do PCR analysis for TERT promoter mutations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of TERT promoter mutations in radioiodine refractory of differentiated thyroid cancer at 12 month after collected specimen Prevalence as percentage | — |
Secondary
| Measure | Time frame |
|---|---|
| Association of TERT promoter mutations and clinicopathological features at 12 months after collected speciment statistical analysis by logistric regression | — |
Contacts
Public ContactThanyalak Samphamtharat
Faculty of Medicine, Chulalongkorn university
Outcome results
None listed