Pulmonary tuberculosis was defined by exhibited chronic cough more than 2 weeks with or without hemoptysis,
Conditions
Interventions
treated with once daily standard drug regimen
in intensive phase of tuberculosis treatment including isoniazid (INH) 5 mg/kg,
rifampicin (RIF) 10 mg/kg,
pyrazinamide (PZA) 25 mg/kg and ethambutol (ETB) 15 mg/kg.,same standard drug regimen
and NAC (600 mg,
orally,
twice daily,
14 days along with the start of PTB
treatment.
Active Comparator Drug,Experimental Drug
standard drug regimen,NAC plus standard drug regimen
Sponsors
Khon Kaen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 0 Years
Inclusion criteria
Inclusion criteria: The patients 18 years of age or older who newly diagnosed PTB and agreement to participate in the study will eligible for enrollment.
Exclusion criteria
Exclusion criteria: We will exclude the patients who are pregnant or breastfeeding, known hypersensitivity to NAC, HIV positive, history of massive hemoptysis (NAC may exacerbate severity of hemoptysis), estimating glomerular filtration rate less than 30 mL/min/1.73 m 2 , moribund state, history of porphyria, pre-existing liver disease, known rifampicin and/or multidrug resistance tuberculosis and earlier anti-tuberculosis treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| efficacy of NAC for sputum smear conversion in pulmonary tuberculosis end of 2 weeks, 4 weeks and 8 weeks after treatment event rate,adverse events along period of study event rate ,hospital admission, along period of study event rate ,needed mechanical ventilator, along period of study event rate ,acquired drug resistant regimen, along period of study event rate | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse events along period of study event rate ,hospital admission along period of study event rate ,needed mechanical ventilator along period of study event rate ,acquired drug resistant regimen along period of study event rate | — |
Countries
Thailand
Contacts
Public ContactPantipa Meethonglang
Khon Kaen Hospital
Outcome results
None listed