post total knee arthroplasty postoperative pain Adductor canal block Total knee arthroplasty Bupivacaine Dexmedetomidine Analgesia
Conditions
Interventions
Adductor canal block with 0.25% bupivacaine 20 ml + dexmedetomidine 0.5 mcg/kg is performed postoperatively at the postanesthesia care unit,Adductor canal block with 0.25% bupivacaine 20 ml + normal s
Experimental Drug,Placebo Comparator Drug
group D: bupivacaine plus dexmedetomidine,group C: bupivacaine plus normal saline
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Primary, unilateral TKA under spinal anesthesia Age 18-85 years The American Society of Anesthesiologists (ASA) physical status I-III
Exclusion criteria
Exclusion criteria: Patients in whom the nerve block or spinal block could not be performed Known allergy to any of the study drugs Patients on recent oral opioids in the last 3 months Pregnancy Patients cannot answer the study question or use the PCA device Coagulopathy Body mass index (BMI) of >35 kg/m2 Severe renal insufficiency Severe alcoholic disease Neuromuscular disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1st analgesic rescue duration time after adductor canal block to 1st analgesic analgesic dose received time record in minute (from PCA device record) | — |
Secondary
| Measure | Time frame |
|---|---|
| morphine consumption in 24 hours 24 hour after adductor canal block dose received in mg (from PCA device record),quadriceps muscle strength 48 hour after adductor canal block Lafayette handheld dynamometer (torque),Timed up & go test 48 hour after adductor canal block record the time ,pain score after adductor canal block then 6-hourly for 24 hours numerical rating scale 0-10,patient satisfaction 48 hour after adductor canal block 3-point descriptive verbal scale, 0=not satisfied, 1=satisfied, 2=better than expected | — |
Countries
Thailand
Contacts
Public ContactVachira Udompornmongkol
Rajavithi Hospital
Outcome results
None listed