Total knee replacement Total knee replacement Oral tranexamic acid
Conditions
Interventions
3 capsules of 250mg oral tranexamic acid at 8 hours post-
operative and at the interval of 8 hours until 48 hours post-
operative. ,3 capsules of placebo identical to oral tranexamic acid at 8 hours post-
Experimental Drug,Placebo Comparator Drug
Oral tranexamix acid,Control
Sponsors
Faculty of Medicine, Prince of Songkla university
Faculty of Medicine,
Prince of Songkla university
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients undergoing primary unilateral total knee arthroplasty Diagnosis of primary osteoarthritis of knee Age less than 85 years old
Exclusion criteria
Exclusion criteria: 1. Previous surgery around the affected knee 2. Complex TKA requiring the use of stemmed prosthesis 3. Use of anticoagulant at the time of admission 4. Documented allergy to drug in the study 5. History of deep vein thrombosis or pulmonary embolism 6. Abnormal coagulation at admission International normalized ration > 1.5 Partial thromboplastin time > 1.4x normal Platelet 3x normal Alkaline phosphatase > 5x normal 8. Calculated glomerular filtration rate < 30 mL/min 9. History of acute coronary syndrome or cerebrovascular accident in the past 12 months 10. Active cancer 11. Use of drug with interaction with Tranexamic acid; eg. Tretinoin, Estrogen, Oral contraceptive pill
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total blood loss 72 hour ml | — |
Secondary
| Measure | Time frame |
|---|---|
| Hb level 24 hr , 72 hr g/L,Blood tranfusion 72 hr unit | — |
Countries
Thailand
Contacts
Public ContactVarah Yuenyongviwat
Faculty of Medicine, Prince of Songkla university
Outcome results
None listed