postnatal hypoglycemia in late preterm and term infants neonatal hypoglycemia oral glucose solution asymptomatic hypoglycemia
Conditions
Interventions
D50W 0.4 mL/kg (200 mg/kg glucose) slowly giving orally within 1-2 minutes and follow by oral feeding,Sterile water 0.4 mL/kg (200 mg/kg glucose) slowly giving orally within 1-2 minutes and follow by
Active Comparator Drug,Placebo Comparator Drug
Oral glucose,Placebo
Sponsors
The Siriraj Research Development Fund (Managed by Routine to Research: R2R).
Eligibility
Sex/Gender
All
Age
No minimum to 48 Hours
Inclusion criteria
Inclusion criteria: 1. At least 34-week's GA 2. At least 1 risk factor of postnatal hypoglycemia (preterm, maternal diabetes, SGA, LGA, birthweight less than 2500g or more than 4000g) 3. Asymtomatic hypoglycemia 4. Age less than 48 hours 5. No contraindication of oral feedings 6. Parental written consent
Exclusion criteria
Exclusion criteria: 1. Blood glucose less than 25 mg/dL 2. IV fluid is indicated from other reasons 3. Major anomalies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion of infants require IV glucose administration within 48 hours present of having IV fluid for glucose admistration | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of hyperglycemia during 48 hours number of infants in each arm who have blood glucose >180 mg/dL,days of full enteral feedings during birth hospitalization postnatal days at reaching enteral feeding | — |
Countries
Thailand
Contacts
Public ContactRatchada Kitsommart
Faculty of Medicine Siriraj Hospital
Outcome results
None listed