The role of childhood adversity in cortisol dysregulation in depressed and non-depressed methamphetamine users with and without history of suicide

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20181119002

Enrollment

195

Registered

2018-11-19

Start date

2014-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

All stages of the research were performed after obtaining informed consent from patients and based on the latest version of the Helsinki Convention. Cortisol&#44

Interventions

merely dependent on methamphetamine,patients with a history of methamphetamine dependency with the diagnosis of depressive comorbidity and history of suicide attempts

Basic Science,Basic Science

merely dependent on methamphetamine,patients with a history of methamphetamine dependency with the diagnosis of depressive comorbidity

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (a) age of 18 to 65 years; (b) a history of at least two years of continuous consumption of methamphetamine by a vapor inhalation model about 0.5 to 1 g/day; (c) a diagnosis of drug dependence and MDD based on DSM-5 criteria and history of suicide attempt in the past or the existence of suicidal ideation in the last 12 months; (d) being in the abstinence phase for at least six and not more than 12 months and the presence of PAWS in the depressed group; (e) the history of suicide attempt at least once and at most three times; (f) body mass index (BMI) between 18 and 35 kg; and (g) lack of suicide attempts and suicidal ideation in the control group.

Exclusion criteria

Exclusion criteria: (a) history of seizure, head trauma, endocrine disruptions, cardiovascular disease or other specific chronic diseases; (b) treatment in the last 6 months with antidepressants, neuroleptics, sedatives, glucocorticoids, appetite suppressants, estrogens, dopamine medications; (c) Experience of any extraordinary stress at present; and (d) pregnancy, hormone intake, or any cortisol simulants or suppressants. Money was paid to people for their contributions.

Design outcomes

Primary

Measure	Time frame
childhood adversity 12-week Childhood Trauma Questionnaire (CTQ),depressive symptomatology 12 weeks Beck Depression Scale (BDI)	—

Secondary

Measure	Time frame
Suicidal ideation 12-weeks Beck Scale for Suicidal Ideation (BSS),Saliva Cortisol Measurements 12 weeks enzyme-linked immunosorbent assay (ELISA)	—

Countries

iran

Contacts

Public Contactbijan pirnia

Bijan Center

b.pirnia@usc.ac.ir+9802122081450

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

The role of childhood adversity in cortisol dysregulation in depressed and non&#45;depressed methamphetamine users with and without history of suicide