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Prefrontal cortex in aging and effect of aquatic therapy-from ANS and executive function perspective (PART II)

Prefrontal cortex in aging and effect of aquatic therapy-from ANS and executive function perspective (PART II)

Status
Unknown
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20181116001
Enrollment
120
Registered
2018-11-16
Start date
2022-06-16
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

elderly Mild cognitive impairment (MCI) Prefrontal cortex Autonomic nervous system Executive function aquatic therapy cognitive impairment

Interventions

Subjects in this group will receive aerobic cycling exercise as active control. Every session will consist 10 min of warm&#45
up exercise&#44
30 min of aerobic exercise with moderate intensity&#44
and final 10 min of cool&#45
down exercise. The moderate intensity of aerobic exercise will start with 40% of heart rate reserve (HRR) and progress to 70% HRR.,We will use Ai Chi as the aquatic exercise. Subjects will practice Ai
with temperature at 34°. Clinical Ai Chi (CAC) consists of 16 original movements and complemented by 3 movements from Tai Chi to a total of 19. The movements are categorized as breathing exercise&#44
trunk stability&#44
basic coordination&#44
advanced coordination and Tai Chi. In the first 6 weeks&#44
subjects will learn 19 movements in sequence with weekly progression of 3&#45
4 new movements with 10&#45
15 repetitions for each movement. Breathing exercise is included in every session. In the last 2 weeks&#44
all movements will be mixed and practiced in an alternative sequence.
Active Comparator Other,Experimental Other
aerobic training,aquatic therapy

Sponsors

National Yang Ming Chiao Tung University, Taiwan
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) older adults age between 65 and 80 y/o (2) Mini-mental status examination (MMSE) in no less than 24 points (3) Montreal cognitive assessment (MoCA) is no less than 24 points as healthy and < 26 as MCI (4) Walk independently (without assistive devices) for at least 10 m

Exclusion criteria

Exclusion criteria: (1) Unstable medical conditions (2) MMSE < 24 (3) Neurological, cardiac disease, or learning disability (4) Ongoing regular aquatic exercise program (5) Contraindication for exercise and hydrotherapy

Design outcomes

Primary

MeasureTime frame
prefrontal cortex activity pre-test, post-test, 3-month follow-up, 6-month follow-up function near-infrared spectroscopy (fNIRS),autonomic nervous control pre-test, post-test, 3-month follow-up, 6-month follow-up heart rate variability,executive function pre-test, post-test, 3-month follow-up, 6-month follow-up Trail Making Test A, B,executive function pre-test, post-test, 3-month follow-up, 6-month follow-up Stroop Color and Word Test

Secondary

MeasureTime frame
single and sual task walking ability pre-test, post-test, 3-month follow-up, 6-month follow-up GAITRite system for spatiotemporal parameters under single task and dual task,fall risk pre-test, post-test, 3-month follow-up, 6-month follow-up the number of fall episodes in the past 6 months,quality of life pre-test, post-test, 3-month follow-up, 6-month follow-up 36-Item Short-Form Health Survey (SF-36)

Countries

Taiwan

Contacts

Public ContactRay Yau Wang

Department of Physical therapy and Assistive Technology, National Yang Ming Chiao Tung University

rywang@nycu.edu.tw886228267210

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026