Ischemic stroke Thrombolysis Door-
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Diagnosis of ischemic stroke causing measurable neurological deficit 2.Onset of symptoms <4.5 hours before beginning treatment 3.Aged ≥18 years
Exclusion criteria
Exclusion criteria: 1.Significant head trauma or prior stroke in previous 3 months 2.Symptoms suggest subarachnoid hemorrhage 3.Arterial puncture at noncompressible site in previous 7 days 4.History of previous intracranial hemorrhage,Intracranial neoplasm, arteriovenous malformation 5.Elevated blood pressure (systolic >185 mm Hg or diastolic >110 mm Hg) 6.Active internal bleeding 7.Acute bleeding diathesis, including but not limited to 8.Platelet count 1.7 or PT >15 seconds 11.Current use of direct thrombin inhibitors or direct factor Xa inhibitors with elevated sensitive laboratory tests (such as aPTT, INR, platelet count, and ECT; TT; or appropriate factor Xa activity assays) 12.Blood glucose concentration 1/3 cerebral hemisphere)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to receive intravenous thrombolysis 60 minutes Door-to-needle time | — |
Secondary
| Measure | Time frame |
|---|---|
| Favorable functional outcome 3 months modified Rankin scale | — |
Countries
Thailand
Contacts
Chulalongkorn University