COMPARISON OF CALCIUM SILICATE APICAL PLUG AND REGENERATIVE ENDODONTIC PROCEDURE IN TREATMENT OF IMMATURE PERMANENT TEETH WITH NECROTIC PULP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20181011002

Enrollment

Registered

2018-10-11

Start date

2018-11-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

immature permanent tooth with necrotic pulp periapical peridontitis

Interventions

OK) will be compacted with pluggers and sterile paper points. If the application of post was necessary&#44

the thicknes of apical plug will be 5mm at minimum. If there was no need of post&#44

the filling ended 3mm below cementoenamel junction. After

Experimental Procedure/Surgery,Active Comparator Procedure/Surgery

Regenerative endodontic procedure,Calcium silicate apical plug

In the regenerative endodontic procedure group&#44

after establishing the working lenght with electronic apexlocator and its radiographic verification&#44

the root canal system will irrigated with 2&#44

5% sodium hypochlorite for 10 minutes and 5 minutes passive ultrasonis irrigation (PUI). After that the root canal system will be continuosly flushed with 17% EDTA for 10 minutes and subsequently will

file ISO25. The blood clot will be stabilized with help of oxidized cellulosis at the level of cementoenamel junction. On the top of stabilized blood clot&#44

the coronal barrier from calcium silicate cement NeoMTA (NuSmile&#44

Texas&#44

USA) will be placed. After that the access cavity will be rinsed with saline&#44

cleaned with microbrush and sandblasted. The access cavity will be adhesively restored.,In the calcium silicate apical plug group&#44

5% sodium hypochlorite for 10 minutes and 5 minutes passive ultrasonis irrigation (PUI). After that the root canal system will be flushed with 5ml 17% EDTA and subsequently will be rinsed with 10ml 2&

5% sodium hypochlorite. Before drying root canal with sterile paper points the remnants of sodium hypochlorite will be rinsed with saline. The calcium silicate cement (ProRoot MTA White&#44

Dentsply Maillefer&#44

Tulsa&#44

Eligibility

Sex/Gender

All

Age

7 Years to 11 Years

Inclusion criteria

Inclusion criteria: immature permanent tooth with necrotic pulp (Cvek classification I.-IV.)

Exclusion criteria

Exclusion criteria: external inflammatory or replacement resorption

Design outcomes

Primary

Measure	Time frame
presence of apical periodontitis 2 years periapical index	—

Secondary

Measure	Time frame
root area 2 years radiological root area	—

Countries

Czech Republic

Contacts

Public ContactRadovan Å½iÅ¾ka

Czech Educational and Dental Research Innovative Group

loupaczech@gmail.com00420724143590

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026