Effect of influenza vaccination on level of phenytoin in Thai epileptic patients treated with phenytoin

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20181007001

Enrollment

Registered

2018-10-07

Start date

2018-10-08

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epileptic patients treated with Phenytoin Influenza vaccine&#44

Interventions

Influenza vaccination on level of phenytoin in Thai epileptic patients treated with phenytoin

Experimental Drug

Influenza vaccine

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Epilepsy age 18-55 years 2. Treated with Phenytoin monotherapy

Exclusion criteria

Exclusion criteria: 1. Contraindication of vaccine 2. Liver disease 3. Concomitant drugs that have effect on CYP2C9/2C19 4. Active infection or got infected within 2 weeks

Design outcomes

Primary

Measure	Time frame
Phenytoin level, interferon-ð›¾, oxidative enzyme(CYP2C9) day 0,1,4,7,14 chemiluminescent microparticle immunoassay(CMIA), Enzyme-linked immunosorbent assay (ELISA)	—

Secondary

Measure	Time frame
Adverse events during study interview	—

Countries

Thailand

Contacts

Public ContactAtiwat Soontornpun

Faculty of Medicine, Chiang Mai University

asoontornpun@gmail.com66896322686

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026