Comparison of effectiveness of regimen for switching from morphine to Methadone between stop and go method and 3 days method in cancer patients in Siriraj Hospital : A randomized clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20181003001

Enrollment

100

Registered

2018-10-03

Start date

2018-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cancer cancer methadone switching

Interventions

stop morphine and switch to Methadone in one day, switch from morphine to Methadone within 3 days by replacing 1/3 dose of morphine with Methadone each day

Active Comparator Drug,Active Comparator Drug

stop and go method,three day method

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: cancer pain patients moderate to severe pain MME more than 40 mg age more than 18 years old

Exclusion criteria

Exclusion criteria: non cancer patients vital sign unstability communication problem patients don't know the cancer diagnosis

Design outcomes

Primary

Measure	Time frame
effectiveness of regimen for switching from morphine to Methadone 28 days brief pain inventory and ESAS score	—

Secondary

Measure	Time frame
adverse events 28 days sedation score, nausea and vomiting and constipation	—

Countries

Thailand

Contacts

Public ContactPranee Rushatamukayanunt

department of anesthesiology

pnrusha@gmail.com0876726014

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026