Hemodialysis patients who have history of intradialytic hypotension Intradialytic hypotension Chronic hemodialysis Sertraline Hemodialysis complication
Conditions
Interventions
Sertraline will be started at the dose of 50 mg/day (1 tablet once daily) during the first week and will be increased to the 100 mg/day (1 tablet twice daily) from week 2 to week 4.,Matching placebo w
Experimental Drug,Placebo Comparator Drug
Sertraline,Placebo
Sponsors
Renal Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age of 18 years old or older 2. End-stage renal disease (ESRD) patients (defined by Kidney Disease Initiative Global Outcome (KDIGO) Guideline 2012) requiring chronic hemodialysis 3. Hemodialysis vintage of more than 3 months 4. Hemodialysis with 3 sessions per week 5. History of intradialytic hypotension in at least 25% of their dialysis sessions during the past 2 months
Exclusion criteria
Exclusion criteria: 1. Active cardiac disease 2. Sepsis or septic shock 3. Require ultrafiltration of more than 3.5 L per session 4. Active malignancy 5. Prior treatment with Selective serotonin reuptake inhibitors (SSRIs) in the past 4 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intradialytic hypotension 4 weeks Defined according to Kidney Disease Outcome Quality Initiative (KDOQI) Guideline 2005 | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A,N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactKajohnsak Noppakun
Chiang Mai University
Outcome results
None listed