Active lupus nephritis Serum uromodulin Lupus nephritis Biomarker Remission
Conditions
Interventions
Patients with active lupus nephritis as defined in the inclusion criteria who require induction therapy according to physician opinion
Diagnostic
Patients with active lupus nephritis requiring induction therapy
Sponsors
Renal Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age of 18 or older 2. Diagnosed systemic lupus erythematosus (SLE) according to 1997 American College of Rheumatology (ACR) criteria 3. Patients with active lupus nephritis requiring induction therapy according to physician opinion. However, kidney biopsy to confirm lupus nephritis is not required. Active lupus nephritis is defined as one of the following: 3.1 Presence of urine protein of more than 0.5 gram per day and presence of red blood cells (RBC) in urine of more than 5 cells per high power field or presence of RBC cast or 3.2 Presence of urine protein of more than 3.0 gram per day if RBC in the urine less than 5 cells per high power field and no RBC cast 3.3 If kidney biopsy was done, presence of the evidence of active lupus nephritis class III, IV or V according to the 2003 International Society for Nephrology/Renal Pathology Society (ISN/RPS) classification criteria
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Patients with antiphospholipid syndrome (APS) 3. Patients with thrombotic thrombocytopenic purpura (TTP) 4. Patients with overlapping syndrome 5. Patients who have estimated glomerular filtration rate (eGFR) less than 30 ml/min/1.73 m2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response to induction therapy Six months after induction therapy Serum creatinine, urine protein, and urine analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactKajohnsak Noppakun
Chiang Mai University
Outcome results
None listed