Nasal High Flow Versus Conventional Oxygen Therapy in Emergency Department Patients With Asthma Exacerbation and Hypoxemia: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20180926003

Enrollment

Registered

2018-09-26

Start date

2019-03-22

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

asthma

Interventions

High flow nasal cannula (NHF) is a relatively new innovation. This cannula can deliver gases across a range of flows 2&#45

60 L/min and FiO2 at 0.21&#45

1.0% which is enough to generate positive airway pressure and could decrease work of breathing in participants with dyspnea. The gas delivered from the high flow device used with this cannula is warme

rebreather mask

Experimental Device,Active Comparator Device

Nasal high flow,Conventional oxygen therapy

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients with age of 18 years or older 2. Patients who previously diagnosed with asthma according to GINA guideline 3. Patients who present with symptoms compatible with exacerbation according to GINA guideline (progressive increase in symptoms of shortness of breath, cough, wheezing or chest tightness and progressive decrease in lung function) 4. Patients with hypoxemia defined as SpO2 at room air of less than 95%

Exclusion criteria

Exclusion criteria: 1. Patients with respiratory failure; defined as respiratory rate >35 breaths/min, SpO2 5 pack/year 7. Patients concurrently diagnosed with other lower airway conditions such as pneumonia, pulmonary edema 8. Patients who decline to participate 9. Pregnant patients

Design outcomes

Primary

Measure	Time frame
Modified Borg scale 120 minutes direct asking or questionnaire,Numeric rating scale 120 minutes direct asking or questionnaire	—

Secondary

Measure	Time frame
Respiratory rate 120 minute Direct observation for one full minute,Oxygen saturation 120 minutes Pulse oxymeter,Comfort scale 120 minutes visual analog scale,Peak expiratory flow rate 120 minute peak flow meter,NIV and intubation rate 24 hours medical record review,ED and hospital length of stay after discharge medical record review	—

Countries

Thailand

Contacts

Public ContactOnlak Ruangsomboon

Faculty of Medicine, Siriraj Hospital Mahidol University

onlak.rua@gmail.com+66877853385

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026