Patient with septic shock septic shock,
Conditions
Interventions
Vitamin C 1.5 gm add in 0.9% NaCl 100 ml iv drip in 30 min q6h x 4 days or until vasopressor was stopped for 24 hr with standard treatment,NSS 100 ml iv drip in 30 min q6h x 4 days or until vasopresso
Experimental Drug,Placebo Comparator Drug
Vitamin C group,Placebo group
Sponsors
Bhumibol Adulyadej Hospital Fund
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age over 18 year-old and less than 80 year-old 2. Septic shock is diagnosed in ER. (SIRS criteria ≥2 or qSOFA ≥2, require vasopressor for keeping MAP > 65 mmHg and serum lactate > 2 mmol/L)
Exclusion criteria
Exclusion criteria: 1. Can not start intervention within 24 hours after septic shock is diagnosed 2. Prior antioxidant use eg. N-acetylcysteine, vitamin E, selenium, coenzyme Q10 3. There are contraindications for intravenous vitamin C (Allergic to vitamin C, bilateral ureteric obstruction, chronic hemodialysis, iron overload, oxalate stone former, hemochromatosis, G6PD deficiency and sickle cell disease) 4. Pregnant or breastfeeding woman 5. Patient who survives following CPR 6. Palliative care patients 7. Patients who will be enrolled in this study previously. 8. Patients who will be enrolled in other drug trials within 30 days before enrolment in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all cause mortality 28 days visit in person, telephone contact | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity changing 4 days SOFA score | — |
Countries
Thailand
Contacts
Public ContactWoottipong Chanto
Bhumibol Adulyadej hospital
Outcome results
None listed