Beta-
Conditions
Interventions
Oral sildenafil at least 60 mg/day plus inhaled nebulized nitrite 15 mg BID,Oral sildenafil at least 60 mg/day
Experimental Drug,Active Comparator Drug
Oral sildenafil plus inhaled nebulized nitrite,Oral sildenafil
Sponsors
Department of Pharmacology at Faculty of Science, Mahidol University
Cooley'
s anemia foundation
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Age ≥ 18 years old Beta-thalassemia patients diagnosed with pulmonary hypertension type 5 (WHO criteria) Right heart catheterization ; MPAP ≥ 25 mmHg and PCWP < 15 mmHg TR Vmax ≥ 2.8 m/s or RVSP ≥ 35 mmHg will undergo to right heart catherization
Exclusion criteria
Exclusion criteria: -Currently use organic nitrate -Currently treated with other PAH -specific drugs (except sildenafil) -Hb 4% -Symptomatic left sided heart failure -History ischemic heart disease -COPD -Uncontrolled DM -Uncontrolled thyroid disorder -Cirrhosis -Pregnancy -No inform consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of six minute walk test 3 months Standard 6 minutes walk test measurement | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of echocardiography 3 months Echocardiogram,change of NTproBNP 3 months Blood for NTproBNP | — |
Countries
Thailand
Contacts
Public ContactThinnakrit Sasirapha
Cardiology fellowship
Outcome results
None listed