Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) AECOPD Chronic obstructive pulmonary disease Exacerbation None invasive ventilation NIV None invasive positive pressure ventilation NIPPV BiPAP S/T Average Volume Assured Pressure Support AV
Conditions
Interventions
Patient with AECOPD enrolled to NIV with AVAPS mode ,Patient with AECOPD enrolled to NIV with BiPAP S/T mode
Experimental Device,Active Comparator Device
AVAPS ,BiPAP S/T
Sponsors
Siriraj Hospital
Siriraj Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >,= 18 years old 2. Patients with COPD presented with respiratory distress meeting at least one of the following criteria - Pulse oximetry < 90% when breathing at room air - Signs of respiratory distress e.g. accessory muscle use - Respiratory rate ≥ 30 breaths/min - ABG show acute respiratory acidosis determined by ED physician
Exclusion criteria
Exclusion criteria: 1. Refusal of treatment 2. Agitation or non-cooperation 3. Facial deformity 4. Obstruction in the upper airway from surgery or trauma 5. Alterations of the central nervous system not related to hypercapnic encephalopathy (GCS <9) 6. Cardiogenic pulmonary edema 7. Pneumothorax 8. Pulmonary thromboembolism 9. Hemoptysis or septic shock 10. Emergency intubation due to acute respiratory failure or cardiopulmonary arrest 11. Hemodynamic instability with systolic pressure below 90 mmHg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| compare the decrease in degree of dyspnea initial T0 and 60 minutes post intervention Modified Borg scale and numeric rating scale, and dyspnea and comfort scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiration rate initial T0 and 60 minutes post intervention time per minute,SpO2 initial T0 and 60 minutes post intervention %/by portable machine,NIV failure initial T0 and 60 minutes post intervention yes/no,GCS initial T0 and 60 minutes post intervention number 3 to 15,PaCO2 initial T0 and 60 minutes post intervention percentage/arterial blood gas,Heart rate initial T0 and 60 minutes post intervention beat per minute | — |
Countries
Thailand
Contacts
Public ContactChok Limsuwat
Mahidol university, Siriraj Hospital
Outcome results
None listed