wound healing of tooth extraction socket Vitamin C Ascorbic acid Tooth extraction Wound healing
Conditions
Interventions
Each patient will be prescribed placebo tid pc for 10 days after the first tooth extraction. After 21 days,
the other side of the tooth will be extracted and the patient will be prescribed vitamin C 200 mg tid pc for 10 days.,Each patient will be prescribed placebo tid pc for 10 days after the first tooth e
the other side of the tooth will be extracted and the patient will be prescribed vitamin C 500 mg tid pc for 10 days.,Each patient will be prescribed vitamin C 200 mg tid pc for 10 days after the firs
the other side of the tooth will be extracted and the patient will be prescribed vitamin C 500 mg tid pc for 10 days.
Vitamin C 200 mg,Vitamin C 500 mg,Compare dose
Sponsors
Chulalongkorn University
Eligibility
Sex/Gender
All
Age
14 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Patients who have bilaterally symmetrical non-infected premolars needed for extraction, which are usually extracted to make space for orthodontic treatment. Dental caries and retained roots with no periapical lesions or abscess are included. 2.No odontogenic related local or space infection 3.Aged 14-40 years old 4.Absence of uncontrolled medical condition including diabetes mellitus, hematological disorders, immunocompromised or American Society of Anaesthesiologist (ASA) Physical Status I or II
Exclusion criteria
Exclusion criteria: 1.Smokers or alcoholics 2.On drug therapy which may interfere with wound healing such as corticosteroids 3.Pregnant or lactating women and taking estrogen-containing contraceptive drugs 4.Psychiatric patients 5.Patients who cannot cooperate with the study and post-operative follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The healing of the extraction wound Immediately after tooth extraction, on the 7th and 21st day post-extraction The size of the extraction socket measured by using caliper and periodontal probe,The healing of the extraction wound On the 7th and 21st day post-extraction Toluidine blue staining | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain The first three days post-extraction VAS | — |
Countries
Thailand
Contacts
Public ContactNanthanut Pisalsitsakul
Outcome results
None listed