Effects of Serum Bicarbonate Level on a Decline of Muscle Mass and Strength among Pre-dialysis Chronic Kidney Disease Patients with Metabolic Acidosis: A Randomized Controlled Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20180823003

Enrollment

Unknown

Registered

2018-08-23

Start date

2018-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle mass and strength chronic kidney disease metabolic acidosis muscle mass

Interventions

oral sodamint tablets to keep serum bicarbonate level 22 mmol/L,oral sodamint tablets to keep serum bicarbonate level 26 mmol/L

Experimental Drug,Experimental Drug

serum bicarbonate 22 mmol/L,serum bicarbonate 26 mmol/L

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. CKD stage 3-4 (estimated GFR 15-59 ml/min/m2) patients 2. Serum bicarbonate < 22 mmol/L

Exclusion criteria

Exclusion criteria: 1. Neuromuscular diseases 2. Autoimmune or tranplnted patients who currently receiving immunosuppressive agents (steroids included) 3. Rapidly declining of eGFR 4. Resistant hypertension 5. Fluid overload or heart failure status 6. Morbid obesity (BMI > 35 kg/m2) 7. Patients with cardiac devices

Design outcomes

Primary

Measure	Time frame
Change of muscle mass 6 months Mid arm muscle circumference	—

Secondary

Measure	Time frame
Change of muscle mass, eGFR 6 months BIA, BIS, serum creatinine	—

Countries

Thailand

Contacts

Public ContactSomrath Srijaruneruang

Faculty of Medicine Chulalongkorn Universirty

au_alazka@hotmail.com+66869057400

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Effects of Serum Bicarbonate Level on a Decline of Muscle Mass and Strength among Pre&#45;dialysis Chronic Kidney Disease Patients with Metabolic Acidosis: A Randomized Controlled Trial