Comparison of Pretreatment with Combination of Ondansetron/Dexamethasone and Lidocaine on Propofol Injection Pain During Induction

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20180822003

Enrollment

Unknown

Registered

2018-08-22

Start date

2017-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients ASA physical status I &#45

Interventions

Patient will be injected Ondansetron 4 mg and Dexamethasone 10 mg before propofol injection,Patient will be injected Lidocaine 40 mg before propofol injection

Active Comparator Drug,Active Comparator Drug

Ondansetron 4 mg/Dexamethasone 10 mg,Lidocaine 40 mg

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Patients ASA physical status I - III 2. Age group between 20 and 60 years old 3. Undergo elective surgery under general anesthesia

Exclusion criteria

Exclusion criteria: 1. History of 5-HT3 antagonist hypersensitivity 2. History of Propofol, egg and soybean hypersensitivity 3. Infected patient 4. History of lipid metabolism disorder 5. Chronic pain/analgesic received

Design outcomes

Primary

Measure	Time frame
Pain intensity of propofol injection after pretreatment after propofol injection 10 seconds Numeric scale	—

Secondary

Measure	Time frame
Side effect of pretreatment after injection of pretreatment Incidence of nausea and vomiting, perinium irritation	—

Countries

Thailand

Contacts

Public ContactPrateep Lertmongkonaksorn

Faculty of Medicine, Ramathibodi hospital, Mahidol university

b_arbitats@hotmail.com0865086236

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026