Healthy young and old adults Mild cognitive impairment (MCI) Prefrontal cortex Autonomic nervous system Executive function cognitive impairment
Conditions
Interventions
The participants in this group will be 20 to 30 years old,
cognitively normal (MMSE>24),
and without any considerable history of neurological or cardiac disease. ,The participants in this group will be 65 to 80 years old,
and without any considerable history of neurological or cardiac disease. ,The participants in this group will be 65 to 80 years old who are normal in general cognitive function (MMSE>24) but slightly
and without any considerable history of neurological or cardiac disease.
Screening,Screening,Screening
Healthy young adults,Healhty old adults,Elderly with MCI
Sponsors
National Health Research Institute, Taiwan
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) young adults age between 20 and 30 y/o (2) older adults age between 65 and 80 y/o (3) Mini mental status examination (MMSE) > 24 points (4) Montreal cognitive assessment (MoCA) > 26 points as healthy and < 26 as MCI (5) Walk independently (without assistive devices) for at least 10 m
Exclusion criteria
Exclusion criteria: (1) Unstable medical conditions (2) MMSE < 24 (3) Neurological, cardiac disease, or learning disability (4) Ongoing regular aquatic exercise program (5) Contraindication for exercise and hydrotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| executive function It will be assessed after enrollment Stroop Color and Word Test,executive function It will be assessed after enrollment Trail Making Test A, B,autonomic nervous control It will be assessed after enrollment heart rate variability,prefrontal cortex activity It will be assessed after enrollment function near-infrared spectroscopy (fNIRS) | — |
Secondary
| Measure | Time frame |
|---|---|
| working memory It will be assessed after enrollment Digit Span Test | — |
Countries
Taiwan
Contacts
Public ContactRay-Yau Wang
Department of Physical therapy and Assistive Technology, National Yang Ming University
Outcome results
None listed