severe cutaneous adverse reactions SCARs cutaneous adversed reactions antituberculosis first line antituberculosis drugs SJS TEN DRESS AGEP severe cutaneous adverse reactions SCARs cutaneous adversed reactions antituberculosis first line antituberculosis drugs SJS TEN DRESS AGEP
Conditions
Interventions
Adverse reaction report that were reported Stevens-
Johnson syndrome,
drug reactions with eosinophilia and systemic symptoms,
acute generalized exanthematous pustulosis and toxic epidermal necrolysis
Supportive Care
Report of patients occured SCARs
Sponsors
Tipsiri Chaikong
Tipsiri Chaikong
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. reports that the culprit drugs was Isoniazid, Rifampin, Pyrazinamide, Ethambutol, Streptomycin 2. reports that adverse reactions was Stevens-Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN), Drug reaction with eosinophilia and Systemic symptoms/ Drug-induced hypersensitivity syndrome (DRESS/ DIHS), Acute Generalized Exanthematous Pustulosis (AGEP) or the rash that was reported to be serious rash
Exclusion criteria
Exclusion criteria: The report that these data incompleted; report date, gender, age, drug allergy history, culprit drug name, start date, stop date, ADRs occurrence date, ADRs, causality relationship, seriousness of reactions, patient result from SCARs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of severe cutaneous adverse reaction 5 months Descriptive Statistics (frequency of severe cutaneous adverse reaction per 1000 patients by using PS | — |
Secondary
| Measure | Time frame |
|---|---|
| relationship between outcome and type of severe cutaneous adverse reactions 5 months chi square, logistic regression(95% confidence interval, odd ratios), Significant alpha 0.05 | — |
Countries
thailand
Contacts
Public ContactTipsiri Chaikong
Faculty of Pharmacy, Silpakorn University
Outcome results
None listed