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A comparison between Lactate Ringer's solution,Hatastarch and Gelatin co-loading in the prevention of hypotension induced by spinal anesthesia in cesarean section

A comparison between Lactate Ringer's solution,Hatastarch and Gelatin co-loading in the prevention of hypotension induced by spinal anesthesia in cesarean section

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20180811001
Enrollment
192
Registered
2018-08-11
Start date
2018-08-30
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy parturients&#44

Interventions

loading fluid was initiated just after intrathecal administration of local anesthetic at a rate of Lactated Ringer’s solution 20 ml/kg in 15 mins or Colloids 500 ml in15 mins.
loading fluid was initiated just after intrathecal administration of local anesthetic at a rate of Lactated Ringer’s solution 20 ml/kg in 15 mins or Colloids 500 ml in15 mins.
Experimental Drug,Experimental Drug,Experimental Drug
Lactated Ringer’s solution 20 ml/kg (group L ) ,HES6%130/0.4 (Voluven 500 ml&#44
group V) &#44
,Gelofusine 500 ml (group G)

Sponsors

Faculty of Medicine, Prince of Songkla University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 45 Years

Inclusion criteria

Inclusion criteria: Healthy parturients at term more than 37 week gestation


Exclusion criteria

Exclusion criteria: - Multiple pregnancy, pre-eclampsia, known fetal compromise - Maternal cardiac disease, CKD stage III(GFR of less than 60 ml/min/1.73m) - Sepsis - Chronic hypertension - Coagulopathy, anemia (Hb 100 kg - History of previous allergy to gelatin and starch

Design outcomes

Primary

MeasureTime frame
incidence of hypotension 15 mins blood pressure (SBP,DBP,MAP),incidence of hypotension 15 mins blood pressure ,incidence of hypotension 15 mins blood pressure ,incidence of hypotension 15 mins blood pressure

Secondary

MeasureTime frame
nausea and incidence of neonatal outcomes until discharge from PACU Apgar score

Countries

Thailand

Contacts

Public ContactAnunya chaosukum

Faculty of Medicine, Prince of Songkla University

Anunya.chao@gmail.com089-7963721

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026