Allergic rhinitis and house dust mite sensitization allergen immunotherapy rush protocol ILC2 Lin-
Conditions
Interventions
Pediatrics patients indicated for AIT
patients between 5-
18 years old with allergic rhinitis and house dust mite sensitization who are indicated for AIT
Other
Sponsors
Faculty of medicine, Ramathibodi hospital, Mahidol university
Eligibility
Sex/Gender
All
Age
5 Years to 18 Years
Inclusion criteria
Inclusion criteria: -Children aged 5-18 years indicated for allergen-specific immunotherapy -Known case allergic rhinitis and may be with asthma/allergic dermatitis -Evidence of HDM sensitization
Exclusion criteria
Exclusion criteria: History of received immunotherapy in the preceding 5 years or ongoing immunotherapy Uncontrolled asthma and severe atopic dermatitis Coexisting disease : -Malignancy -Active autoimmune disease -HIV infection -Cardiovascular diseases -Immunodeficiency -Anatomical defect of the nose
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Innate lymphoid cell type 2 (ILC2) Before start IT, After rush phase, Maintenance phase, After maintenance 6 months, After maintenance Flow cytometry | — |
Secondary
| Measure | Time frame |
|---|---|
| Total IgE, specific IgE, IgG4, Cytokine (IL-10, TGF-β, IFN-γ, IL-4, IL-5, IL-13) Before start IT, After rush phase, Maintenance phase, After maintenance 6 months, After maintenance ELISA,Size of skin test reactivity to HDM , The maximal tolerated dose to Dp Before start IT, After maintenance 6 months, After maintenance Skin prick test and Nasal provocation test,Clinical signs and symptoms Everyday Clinical and medication scores (DSS, DMS, DCS),Peak nasal inspiratory flow(PNIF) Every visit before injection of IT Nasal peak flow meter | — |
Countries
Thailand
Contacts
Public ContactKornvipa Kittinon
Faculty of medicine, Ramathibodi hospital, Mahidol university
Outcome results
None listed