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A comparison of the efficacy and safety of 10% urea cream and 0.025% tretinoin cream in the treatment of acanthosis nigricans

A comparison of the efficacy and safety of 10% urea cream and 0.025% tretinoin cream in the treatment of acanthosis nigricans

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20180703003
Enrollment
40
Registered
2018-07-03
Start date
2018-08-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acanthosis nigricans Acanthosis nigricans&#44

Interventions

topical 10% urea cream apply once daily on the neck,topical 0.025% tretinoin cream apply once daily on the neck
Active Comparator Drug,Active Comparator Drug
10% Urea,0.025% Tretinoin

Sponsors

Faculty of Medicine, Srinakhariwirot University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to No maximum

Inclusion criteria

Inclusion criteria: The participants aged over 12 years with a diagnosis of acanthosis nigricans

Exclusion criteria

Exclusion criteria: - Vulnerable skin diseases - Infectious skin diseases - Other recent diseases involving the neck - Other serious medical disorders e.g. DM, liver disease - Any patients having received other therapies for up to 4 weeks prior to enrollment. - Photosensitive skin - Immunocompromised host - Pregnancy and lactation - Receiving oral retinoids - Neck tattoo

Design outcomes

Primary

MeasureTime frame
efficacy of treatment week 0, 2, 4 and week 8 Melanin index from Mexameter MX18—

Secondary

MeasureTime frame
efficacy of treatment week 0, 2, 4 and week 8 the investigator’s global evaluation (IGE) scale and the parent’s global evaluation (PGE) scale—

Countries

Thailand

Contacts

Public ContactArucha Treesirichod

Srinakharinwirot University

Trees_ar@yahoo.com66815935232

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026