Prevention of propofol injection pain : A comparison of lidocaine pretreatment and lidocaine pretreatment with the diluted propofol with dextrose water

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20180702004

Enrollment

326

Registered

2018-07-02

Start date

2018-04-17

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain on propofol injection

Interventions

40 mg lidocaine pretreatment before 1%propofol injection,40 mg lidocaine pretreatment before 0.5%propofol injection

No Intervention Drug,Experimental Drug

Lidocaine pretreatment,Lidocaine pretreatment with the diluted propofol with dextrose water

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients go on surgery under general anesthesia Body weight more than 40 kilogram Mean arterial presuure more than 65 mmHg ASA physical status 1 or 2

Exclusion criteria

Exclusion criteria: Chronic pain Allergy to study drug Communication problem

Design outcomes

Primary

Measure	Time frame
Four point pain response scale 15 seconds after drug injection Observing and asking	—

Secondary

Measure	Time frame
Blood pressure and heart rate After drug injection Medical equipment	—

Countries

Thailand

Contacts

Public ContactJittiya Watcharotayangkul

Medical staff

now_cool@hotmail.com0818400486

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026