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Conditions
Interventions
Corneal neurotization (contralateral V1 transposition surgery) to evaluate Clinical outcome and confocal microscopic study of neurotrophic keratopathy
Experimental Procedure/Surgery
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patient who diagnosed CN7&CN5 palsy with Neurotrophic keratopathy - NK stages 2 and 3 (Mackie's classification) - Patient older than 18 years old - Non-response to maximal medical and surgical treatment such as lachrymal substitution, tarsorrhaphy and gold weight implantation - No ocular hypertony in both eyes - Written consent of the patient
Exclusion criteria
Exclusion criteria: - Impossibility of general anesthesia - Herpetic or zoster recurrence in the 6 months prior surgery - Congenital or Bilateral NK - Patient who had diagnosed isolated CN7 palsy or isolated CN5 palsy - Other causes of NK : diabeta mellitus, amylosis, sarcoidosis, multiple sclerosis, vitamin A or B12 deficiency, Sjögren syndrome, GVH disease, topical NSAID, topical beta-blockers, history of refractive surgery. - Mental illness - Patient's unable to understand informations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| What is the pattern of nerve which regenerate to cornea after we performed corneal neurotization Mar 2018 The laser-scanning confocal microscope (HRT3) | — |
Secondary
| Measure | Time frame |
|---|---|
| How to evaluate clinical outcome in patients after corneal neurotization Mar 2018 modified Cochet–Bonnet esthesiometer | — |
Countries
Thailand
Contacts
Public ContactPajongporn Sodngam
Lerdsin hospital
Outcome results
None listed