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RANDOMIZED CLINICAL TRIAL ON CARIES ARREST USING SILVER DIAMINE FLUORIDE AND FLUORIDE VARNISH

RANDOMIZED CLINICAL TRIAL ON CARIES ARREST USING SILVER DIAMINE FLUORIDE AND FLUORIDE VARNISH

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20180624001
Enrollment
300
Registered
2018-06-24
Start date
2018-06-17
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

enamel or dentin active caries (ICDAS 3&#45

Interventions

Prior to applying the agents&#44
the gauze will be used to isolate the tooth. A drop of silver diamine fluoride agent will be placed in a plastic dappen dish&#44
then dip the disposable micro brush in sufficient amount of silver diamine fluoride agent and place on to the lesions. The parents and teacher will be advised to supervise the children not to drink or
varnish is applied onto the lesion. Then&#44
instruct parents and teacher to supervise the children to avoid having hard food at least 2 hours and avoid brushing teeth on the day of application.
Experimental Drug,Experimental Drug
silver diamine fluoride,fluoride varnish

Sponsors

None listed

Eligibility

Sex/Gender
All
Age
1 Years to 3 Years

Inclusion criteria

Inclusion criteria: - Children aged 1-3 years - Patients who have caries at least one surface enamel or dentin active caries (ICDAS 3-6) - Voluntary under the written consent of parents or caregivers - Children who have no major systemic diseases or on long term medication - Children who have no allergy to fluoride or silver agent or Colophony agents which is ingredient in plaster or other dental materials - Children with the family who have not planned to move to the other district within 2 years - Parents can communicate in Thai language

Exclusion criteria

Exclusion criteria: - Children who having just only enamel caries (ICDAS 1-3) - Tooth with a caries lesion extending into pulpal tissue or having any signs of irreversible pulpitis or non-vital tooth

Design outcomes

Primary

MeasureTime frame
Caries arrest (arrest/not arrest) 6,12,18 months tactile sensation when drawing the probe across the lesion

Secondary

MeasureTime frame
N/A N/A N/A

Countries

Thailand

Contacts

Public Contactsirinan Mabangkhru
sirinan.mab@gmail.com0882620392

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026