none Parecoxib,
Conditions
Interventions
-
Parecoxib 40 mg IV q 12 hour total 4 doses
-
Placebo 1 capsule q 12 hours total 4 doses
*** Placebo = Empty celebrex capsule ***, -
Celecoxib 200 mg po q 12 hour total 4 doses
-
0.9% NSS 2 ml IV q 12 hour total 4 doses
Active Comparator Drug,Active Comparator Drug
Parecoxib groups,Celecoxib groups
Sponsors
Songklanagarind hospital prince of songkla university
Eligibility
Sex/Gender
All
Age
55 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients who is primary osteoarthritis had failed conservative treatment and decided to undergo Total knee surgery. 2. Age over 55 years
Exclusion criteria
Exclusion criteria: 1. Research participants who had allergy to paracetamol, Aspirin, Sulfonamide drug or NSAIDs(Celecoxib or Parecoxib), Opioids 2. Research participants who had Peptic ulcer disease or Inflammatory bowel disease 3. Research participants who had Chronic rheumatoid arthritis 4. Research participants who had Chronic kidney disease[eGFR < 60 mL/min/1.73m2] 5. Research participants who had Heart ischemia 6. Research participants who had Stoke or brain ischemia 7. Research participants who had Primary or seconary cancer 8. Research participants who had Psychotic disease 9. Research participants who had Asthma or Bronchospasm with treat Steroid 10. Research participantsvwho had cognitive impairment 11. Research participants who had American Society of Anesthesiologists (ASA) grade 4–5 12. Research participants were unable to communicate and cooperate with the researcher. 13. Research participants who had under spinal block anesthesia .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain 6 hour, 12hour , 24 hours and 48 hours after TKA Pain score | — |
Secondary
| Measure | Time frame |
|---|---|
| Fentanyl comsumption 24 hours and 48 hours total doses of Fentanyl,Nausea and Vomitting 48 hours number of times,Blood loss 6 hours after surgery milliliter ; modification of the Gross formula,Creatinine Post-op day 3 mg/dL,Creatinine Post-op day 3 mg/dL,ROM of knee Post-op day 1 , Post-op day 2 Goniometer, degrees,Time to walk Still stay hospital hours,Hospital stay When patient is discharge hours,Knee and Osteoarthritis Outcome Score(KOOS) F/U 2 wks , 6 wks after surgery score | — |
Countries
Thailand
Contacts
Public ContactKhanin Iamthanaporn
Orthopedic department, Songklanagarind hospital
Outcome results
None listed