Effectiveness of Plantago major L. extract nanoparticle and Thai massage combined with Plantago major L. extract nanoparticle in patients with osteoarthritis knee

Effectiveness of Plantago major L. extract nanoparticle and Thai massage combined with Plantago major L. extract nanoparticle on pain, physiological and psychological outcomes in patients with osteoarthritis knee

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20180614003

Enrollment

Registered

2018-06-14

Start date

2018-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with osteoarthritis knee Osteoarthritis knee&#44

Interventions

The participants will receive thirty minutes session of Thai massage combined with Plantago major L. extract nanoparticle (natural product) onto the leg including the knee for 12 sessions over a peri

Experimental Other,Experimental Other,Placebo Comparator Other

Thai massage combined with Plantago major L. extract nanoparticle ,Plantago major L. extract nanoparticle ,Sham Plantago major L. extract nanoparticle

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Inclusion criteria

Inclusion criteria: - Age more than 50 years old - The participants have experienced spontaneous knee pain for longer than 12 weeks - Knee crepitus found during knee movement - Knee stiffness are most noticeable when the patient try to get out of bed in the morning - Good communication and cooperation

Exclusion criteria

Exclusion criteria: - A history of the following diseases or disorders: 1. Neurological disorder 2. Knee infection 3. Contagious skin disease in the leg - Leg fracture - Fever

Design outcomes

Primary

Measure	Time frame
Pain Before and after the first treatment session, 1 day and 3 month after end of the intervention Pain scale (visual analogue scale)	—

Secondary

Measure	Time frame
Muscle tension Before and after the first treatment session, 1 day and 3 month after end of the intervention Muscle scale (visual analogue scale),Pressure pain threshold Before and after the first treatment session, 1 day and 3 month after end of the intervention Pressure algometry,Balance Before and after the first treatment session, 1 day and 3 month after end of the intervention Time Up and Go Test,Fear related pain Before and after the first treatment session, 1 day and 3 month after end of the intervention Tampa Scale for Kinesiophobia,Anxiety Before and after the first treatment session, 1 day and 3 month after end of the intervention State anxiety inventory,Muscle activity Before and after the first treatment session, 1 day after end of the intervention Electromyogram (EMG),Patient satisfaction After end of the intervention Patient satisfaction questionnaire	—

Measure

Time frame

Muscle tension Before and after the first treatment session, 1 day and 3 month after end of the intervention Muscle scale (visual analogue scale),Pressure pain threshold Before and after the first treatment session, 1 day and 3 month after end of the intervention Pressure algometry,Balance Before and after the first treatment session, 1 day and 3 month after end of the intervention Time Up and Go Test,Fear related pain Before and after the first treatment session, 1 day and 3 month after end of the intervention Tampa Scale for Kinesiophobia,Anxiety Before and after the first treatment session, 1 day and 3 month after end of the intervention State anxiety inventory,Muscle activity Before and after the first treatment session, 1 day after end of the intervention Electromyogram (EMG),Patient satisfaction After end of the intervention Patient satisfaction questionnaire

—

Countries

Thailand

Contacts

Public ContactVITSARUT BUTTAGAT

School of Health Science, Mae Fah Luang University

vitsarut.but@mfu.ac.th0882674423

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026