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Conditions
Interventions
colchicine 0.6 mg 2 tabs oral at 0 hour
colchicine 1 tab oral at 1 hour,colchicine 1 tab oral at 0 hour
Active Comparator Drug,Active Comparator Drug
loading colchicine,non-
loading colchicine
Sponsors
none
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients aged 18 years or older. - Acute CPPD or gout arthritis within 48 hours, confirmed with synovial fluid examination or diagnosed by ACR/EULAR CLASSIFIACTION CRITERIA FOR GOUT 2015. - Never exposed to uric lowering agent, or use uric lowering agent in stable dose for at lease 30 days. - Prescribed colchicine 0.6 mg. per day or less - Prescribed prednisolon 5 mg. per day or lass
Exclusion criteria
Exclusion criteria: - Co-exiting other causes of arthritis. - Patients who have contraindication to colchicine. - Patient who received analgesic or NSAIDs before included. - eGFR less than 30 by Cockcroft-Gault equation - Patients who cannot estimate pain score - Patients who have significantly severe co-mordities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score reduction after 24 hours 24 hours visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score reduction at 6, 12, and 48 hours 6, 12, and 48 hours visual analog scale,proportion of patients who have at least 50% pain score reduction 24 and 48 hours Pain score reduction after 24 hours,Pain score reduction after 24 hours in patient with eGFR more than 60 and less than 60 24 hours Pain score reduction after 24 hours,sign of inflammation 24 hours scaling score,side effects 24,48 hours record,Patients satsfaction 48 hours visual analog scale | — |
Countries
Thailand
Contacts
Public ContactPloyrung Vechpanich
Maharaj Nakorn Chiang Mai hospital, Chiang Mai University
Outcome results
None listed