A Randomized, Double- Blind, Placebo-Controlled Trial of Pre-emptive Pregabalin on Postoperative pain after Laparoscopic Hysterectomy in Benign Gynecologic disease

Pre-emptive Pregabalin on Postoperative pain after Laparoscopic Hysterectomy in Benign Gynecologic disease

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20180507002

Enrollment

Registered

2018-05-07

Start date

2018-05-08

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain score Postoperative shoulder pain Postoperative quantity of analgesic drug use Adverse effects of pregabalin Pregabalin Postoperative pain Postoperative shoulder pain Laparoscopic hysterectomy

Interventions

A 150 mg pregabalin is given 2 hours before operation,A placebo is given 2 hours before operation

Active Comparator Drug,Placebo Comparator Drug

Pregabalin ,Placebo

Eligibility

Sex/Gender

Female

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Women ages between 18-60 years old 2. Diagnosis for non-cancerous gynecologic disease 3. ASA class 1 or 2 4. BMI < 35 kg/mm2 5. Non emergency surgery conditions 6. Good data communication

Exclusion criteria

Exclusion criteria: 1. Pregabalin or gabapentin allergy 2. Pregnancy or breast feeding women 3. Pathology indicates cancer 4.Known case of Diabetes mellitus, Hypertension, Kidney diseases, or Diseaes, that associates with nausea/vomitting. 5. Known case of Chronic pain disease. 6. Patients who receive other analgesic drugs, anti-emetic drugs or sedative drugs within 24 hours before operation. 7. Patients who have the active-mental disorders 8.Operation time lasts than 4 hours 9.Any complications from operation, for example massive blood loss, injuries to adjacent organs, wound infection etc.

Design outcomes

Primary

Measure	Time frame
postoperative pain 12 hours after administration of pregabalin/ placebo, maximal point of pain visual analog scale	—

Secondary

Measure	Time frame
postoperative pain 6,12, and 24 hour after administration of pregabalin/ placebo visual analog scale,postoperative shoulder pain 6,12, and 24 hours after administration of pregabalin/ placebo visual analog scale,The postoperative quantity of analgesic drug use During 24 hours after administration of pregabalin/ placebo milligrams of fentanyl use by patient controlled analgesia,Adverse effects of pregabalin 48 hours after administration of pregabalin/ placebo Sedation score, nausea/vomitting score	—

Measure

Time frame

postoperative pain 6,12, and 24 hour after administration of pregabalin/ placebo visual analog scale,postoperative shoulder pain 6,12, and 24 hours after administration of pregabalin/ placebo visual analog scale,The postoperative quantity of analgesic drug use During 24 hours after administration of pregabalin/ placebo milligrams of fentanyl use by patient controlled analgesia,Adverse effects of pregabalin 48 hours after administration of pregabalin/ placebo Sedation score, nausea/vomitting score

—

Contacts

Public ContactKhemmanat Sanguanwongthong

Obstetrics and Gynecology Department, Faculty of Medicine, Vajira hospital, Navamindradhiraj univers

jobbyhp@gmail.com0818049894

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

A Randomized&#44; Double&#45; Blind&#44; Placebo&#45;Controlled Trial of Pre&#45;emptive Pregabalin on Postoperative pain after Laparoscopic Hysterectomy in Benign Gynecologic disease