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Single Nucleotide Polymorphisms Influence Methotrexate-resistant in Patients Treated for Low-risk Gestational Trophoblastic Neoplasia

Single Nucleotide Polymorphisms Influence Methotrexate-resistant in Patients Treated for Low-risk Gestational Trophoblastic Neoplasia

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20180430002
Enrollment
40
Registered
2018-04-30
Start date
2018-03-14
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Single nucleotide polymorphisms(SLCO1B1 rs4149056 ABCB1 rs1045642) for patient who had methotrexate&#45

Interventions

Patient with history of gestational trophoblastic neoplasia and complete response to methotrexate treatment,Patient with history of gestational trophoblastic neoplasia and resist to methotrexate treat
Diagnostic,Diagnostic
Methotrexate&#45
sensitive,Methotrexate&#45
resistant

Sponsors

Ratchadapisek Sompoch Endowment Fund
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Non-metastasis, low-risk gestational trophoblastic disease treated with methotrexate Medical records available Maintain contact with the patient Informed consent permission

Exclusion criteria

Exclusion criteria: The patient who received combined methotrexate and other chemotherapy The patient who has contraindication for venipuncture The patient who loss to follow up or expire before study recruitment

Design outcomes

Primary

MeasureTime frame
The impact of certain Single Nucleotide Polymorphism(SNPs) on methotrexate response after treatment and evaluating for response SNPs genotyping—

Secondary

MeasureTime frame
To evaluate other covariates on methotrexate response medical record reviews after informed consent data collection—

Countries

Thailand

Contacts

Public ContactManasawee Srisuttayasathien

Chulalongkorn University

manasawee.sr@hotmail.com0868100234

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026