Comparison of the effect of anesthetic drugs (Sufloran, Propofol, Remifentanil) on biomarkers of injured brain cells in neonates with ages between 6-24 months

Comparison of the effect of anesthetic drugs (Sevoflorane, Propofol, Remifentanil) on biomarkers of injured brain cells in neonates with ages between 6-24 months

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20180426001

Enrollment

Registered

2018-04-26

Start date

2017-12-13

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Injured brain cells Anesthetic drugs&#44

Interventions

This intervention group of study administered Remifentanil.,This intervention group of study administered Propofol.,This intervention group of study administered Sufloran.

Experimental Drug,Experimental Drug,Experimental Drug

Remifentanil, Propofol,Sufloran

Eligibility

Sex/Gender

All

Age

6 Months to 24 Months

Inclusion criteria

Inclusion criteria: All neonates with ASA class1 ranged in age between6-24 months

Exclusion criteria

Exclusion criteria: -Neonates with metabolic disorders - Neonates with seizure - Neonates with history of IVH - Neonates with nervous system disorders - Premature neonates - Systematic disorders

Design outcomes

Primary

Measure	Time frame
Serum level of apoptotic biomarkers of injured brain cells after surgery Before surgery and 1 hour after surgery Experimental kits for each biomarker	—

Secondary

Measure	Time frame
correlation between serum level of apoptotic biomarkers with damage of brain cells after surgery Before surgery and 1 hour after surgery Experimental kits for each biomarker	—

Countries

Iran

Contacts

Public ContactMohammad Gharavifard

Department of anesthesiology, Mashhad university of medical sciences, Mashhad, Iran

gharavim@mums.ac.ir+989151163300

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

Comparison of the effect of anesthetic drugs (Sufloran&#44; Propofol&#44; Remifentanil) on biomarkers of injured brain cells in neonates with ages between 6&#45;24 months